| Discovery Services
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Transgenomic Discovery Services
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Supporting Translational & Clinical Research
with High-Sensitivity Mutation Scanning
and Other Genomic Analysis Services
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- Biomarker Discovery & Validation
- Early Screening
- Patient Stratification
- Prognosis
- Toxicity Prediction
- Assessment of Drug Resistance
- Detection of Metastatic Events
- Residual Disease Monitoring
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Discover the difference . . .
- between research as usual versus allowing the genomic analysis experts at Transgenomic Discovery Services to help take your translational and clinical research to new levels
- by detecting somatic mutations present at frequencies as low as 1.0% or less in heterogeneous samples
- by detecting tumor-associated mutations in plasma or other surrogate samples
- by utilizing genomic data of the highest quality, enabling you to focus your analyses on biological and/or clinical interpretation with total confidence
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| Validated Assays Available for Scanning of More than
700 Genes |
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| Angiogenesis |
Kinases |
Phosphatases |
| Apoptosis |
Mismatch Repair |
Signal Transduction |
| Chromatin Remodeling |
Oncogenes |
Tumor Suppressors |
| Drug Metabolism |
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Sample Acquisition
- Purified DNA/RNA
- Tumor tissue - frozen or paraffin-embedded
- Blood, plasma, other biological fluids
- Many other biological specimens
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PCR Amplification
- Amplicon design
- PCR optimization
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Mutation Scanning with SURVEYOR® Nuclease
- Mismatch cleavage enzyme
- Detects substitutions, insertions/deletions
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Mutation Scanning via Denaturing HPLC (DHPLC)
- Heteroduplex analysis on the WAVE® System
- Detects substitutions, insertions/deletions
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DNA Sequencing & Analysis
- Confirm & identify genetic variation(s)
- In-silico analysis of functional implications
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